Enhancing Host Defence Mechanisms in Severe Bacterial Infections

Grant number: 1142456 | Funding period: 2018 - 2020

Completed

Abstract

New options to treat bacterial infections are needed because of the rapid increase in antibiotic resistance. One very attractive strategy is to boost the body’s own defence mechanisms against bacteria. This project defines novel molecular mechanisms that can be manipulated to better control a bacterial infection. Novel drugs targeting these molecular pathways are already being developed, albeit for cancer. This project will help assess if these drugs may be useful to treat infections.

Related publications (2)

Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages

TT Tran, CD Mathmann, M Gatica-Andrades, RF Rollo, M Oelker, JK Ljungberg, TTK Nguyen, A Zamoshnikova, LK Kummari, OJK Wyer, KM Irvine, J Melo-Bolívar, A Gross, D Brown, JYW Mak, DP Fairlie, KA Hansford, MA Cooper, R Giri, V Schreiber

2022-01-01

A hallmark of Listeria (L.) monocytogenes pathogenesis is bacterial escape from maturing entry vacuoles, which is required for rap..

Myeloid Wls expression is dispensable for skin wound healing and blood vessel regeneration.

Seen Ling Sim, Antje Blumenthal, Simranpreet Kaur, Kiarash Khosrotehrani

2022-01-01

Wnt signaling controls blood vessel growth, regression and patterning during embryonic and postnatal life. Macrophages are major p..

University of Melbourne Researchers

Kim-Anh Le Cao